Immunological Link Between Primary Graft Dysfunction and Chronic Lung Allograft Rejection
نویسندگان
چکیده
منابع مشابه
Acute and Chronic Lung Allograft Rejection
Over the last decade, lung transplantation has become a 'viable option for patients with end-stage lung disease. Due to the relatively small number of lung transplants done nationally, little experience has been gained in the outcome and management of pregnancies in the post-lung transplant patient, and little published data exist to assist the patient's physician regarding issues related to pr...
متن کاملChronic lung allograft rejection: mechanisms and therapy.
Lung transplantation is a therapeutic option for patients with end-stage pulmonary disorders. Unfortunately, due to post-lung transplant complications, both infectious and noninfectious, it is only a treatment and not a cure. Importantly, despite induction combined with triple or quadruple maintenance immunosuppressive therapy, chronic lung rejection, in the form of obliterative bronchiolitis o...
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Transplantation of solid organs is the treatment of choice for most patients with end-stage organ diseases. In the absence of pharmacological immunosuppression, recognition of foreign (allogeneic) histocompatibility proteins expressedondonorcellsby therecipient’s immunesystem results in rejection of the transplanted tissue(s). One-year renal transplant survival is now routinely over 90% in most...
متن کاملChronic lung allograft rejection and airway microvasculature: is HIF-1 the missing link?
Chronic lung allograft rejection, known as obliterative bronchiolitis (OB), is the leading cause of death in lung transplant patients. Although OB pathogenesis is not fully understood, in this issue of the JCI, Jiang and colleagues report that tissue hypoxia resulting in dysfunctional airway microvasculature precedes the airway fibrosis characteristic of OB. In addition, a relative deficiency o...
متن کاملChronic lung allograft dysfunction: evolving practice.
PURPOSE OF REVIEW Chronic lung allograft dysfunction (CLAD) was recently introduced as an overarching term covering different phenotypes of chronic allograft dysfunction, including obstructive CLAD (bronchiolitis obliterans syndrome), restrictive CLAD (restrictive allograft syndrome) and graft dysfunction due to causes not related to chronic rejection. In the present review, we will highlight t...
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ژورنال
عنوان ژورنال: The Annals of Thoracic Surgery
سال: 2008
ISSN: 0003-4975
DOI: 10.1016/j.athoracsur.2008.03.073